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Related Concept Videos

The Retina01:32

The Retina

The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.

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Related Experiment Video

Updated: May 9, 2026

Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks
10:00

Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks

Published on: February 14, 2015

A Retinal Prosthesis Technology Based on CMOS Microelectronics and Microwire Glass Electrodes.

D Scribner, L Johnson, P Skeath

    IEEE Transactions on Biomedical Circuits and Systems
    |July 16, 2013
    PubMed
    Summary
    This summary is machine-generated.

    A novel neural stimulator device for high-resolution retinal prostheses has been developed. This large-format device, combining CMOS electronics and microwire glass, is safe for initial human testing, advancing sight restoration technology.

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    Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis
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    Related Experiment Videos

    Last Updated: May 9, 2026

    Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks
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    Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks

    Published on: February 14, 2015

    Methodology for Biomimetic Chemical Neuromodulation of Rat Retinas with the Neurotransmitter Glutamate In Vitro
    12:56

    Methodology for Biomimetic Chemical Neuromodulation of Rat Retinas with the Neurotransmitter Glutamate In Vitro

    Published on: December 19, 2017

    Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis
    12:01

    Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis

    Published on: August 2, 2013

    Area of Science:

    • Biomedical Engineering
    • Neuroscience
    • Ophthalmology

    Background:

    • High-resolution retinal prostheses are crucial for restoring vision in the blind.
    • Existing technologies face challenges in large-format neural interfacing.
    • The development of advanced neural stimulator devices is essential for progress.

    Purpose of the Study:

    • To design, fabricate, and test a very large format neural stimulator device for retinal prosthesis experiments.
    • To demonstrate a large-format, parallel interface between a microelectronic array and neural tissue.
    • To assess the feasibility of high-resolution retinal prostheses for the blind.

    Main Methods:

    • Designed and fabricated a large-format (80x40 pixels) neural stimulator with 20 microwire electrodes per pixel.
    • Integrated novel components: microwire glass, microelectronic multiplexer, and microcable connector.
    • Employed custom assembly techniques including indium bump bonding, ribbon bonding, and encapsulation.

    Main Results:

    • Successfully designed, fabricated, and tested a large-format neural stimulator device.
    • Demonstrated a viable approach for high-resolution retinal prostheses using conventional CMOS electronics and microwire glass.
    • Device's temperature and electrical output are acceptable for acute human tests.

    Conclusions:

    • The combination of CMOS electronics and microwire glass is a feasible approach for high-resolution retinal prostheses.
    • The developed device is suitable for short-term implantation in human retinas.
    • This work resolves key issues in the development of advanced retinal prosthesis technology.