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Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
Published on: June 23, 2013
Investigation of macrophage polarization using bone marrow derived macrophages
Wei Ying1, Patali S Cheruku, Fuller W Bazer
1Department of Animal Science, Texas A&M University, TX, USA.
Journal of Visualized Experiments : Jove
|July 16, 2013
Abstract:
The article describes a readily easy adaptive in vitro model to investigate macrophage polarization. In the presence of GM-CSF/M-CSF, hematopoietic stem/progenitor cells from the bone marrow are directed into monocytic differentiation, followed by M1 or M2 stimulation. The activation status can be tracked by changes in cell surface antigens, gene expression and cell signaling pathways.
