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Chronic pancreatitis
Matthew J DiMagno1, Eugene P DiMagno
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109-0682, USA. mdimagno@umich.edu
Current Opinion in Gastroenterology
|July 16, 2013
Summary
Celiac disease increases pancreatitis risk. Chronic pancreatitis diagnosis may improve with artificial neural network analysis of endoscopic ultrasonography images, and pain management depends on pain type and intervention timing.
Area of Science:
- Gastroenterology
- Clinical Medicine
- Medical Diagnostics
Background:
- Celiac disease is identified as a risk factor for pancreatitis.
- Recurrent acute pancreatitis may indicate chronic pancreatitis, with limited benefit from sphincterotomy procedures.
Purpose of the Study:
- To review significant clinical observations in pancreatitis and chronic pancreatitis management from 2012.
- To highlight advancements in diagnostic tools and treatment strategies for pancreatitis.
Main Methods:
- Review of clinical observations and multicenter randomized controlled trials.
- Analysis of endoscopic ultrasonography (EUS) images using artificial neural network (ANN) programs.
- Evaluation of pancreatin enzyme replacement therapy for fat malabsorption.
Main Results:
- Celiac disease is a risk factor for pancreatitis.
- Artificial neural network analysis of EUS images shows potential for improved chronic pancreatitis diagnosis.
- 90,000 USP units of pancreatin with meals effectively reduced fat malabsorption in chronic pancreatitis patients.
- Pain management strategies depend on pain origin (visceral vs. nonvisceral) and patient factors.
Conclusions:
- Individuals with celiac disease face an elevated risk of pancreatitis.
- Artificial neural network analysis of EUS imaging can enhance chronic pancreatitis diagnosis.
- Effective treatment of fat malabsorption necessitates 90,000 USP units of lipase per meal.
- Pain relief in chronic pancreatitis is contingent on intervention timing and the nature of the pain (visceral or nonvisceral).
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