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Related Experiment Video

Updated: May 9, 2026

Qualitative and Comparative Cortical Activity Data Analyses from a Functional Near-Infrared Spectroscopy Experiment Applying Block Design
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Qualitative and Comparative Cortical Activity Data Analyses from a Functional Near-Infrared Spectroscopy Experiment Applying Block Design

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New method of analyzing NIRS data from prefrontal cortex at rest.

Wakana Ishikawa1, Masakaze Sato2, Yukikatsu Fukuda2

  • 1Department of Electrical Engineering and Bioscience, Waseda University, Tokyo, Japan. ishikawa10@matsumoto.eb.waseda.ac.jp.

Advances in Experimental Medicine and Biology
|July 16, 2013
PubMed
Summary

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This study introduces a simple method to objectively assess mental stress using near-infrared spectroscopy (NIRS) to measure brain activity in the prefrontal cortex (PFC). Higher prefrontal cortex (PFC) asymmetry at rest correlated with increased anxiety, offering a new tool for stress evaluation.

Area of Science:

  • Neuroscience
  • Psychophysiology
  • Biomedical Engineering

Background:

  • Objective assessment of mental stress is crucial for understanding and managing psychological well-being.
  • Previous methods for stress assessment often rely on subjective reports or complex physiological monitoring.
  • The prefrontal cortex (PFC) plays a significant role in emotional regulation and stress response.

Purpose of the Study:

  • To develop a simple, objective technique for assessing mental stress levels.
  • To utilize two-channel near-infrared spectroscopy (NIRS) to measure hemoglobin concentration changes in the bilateral PFC at rest.
  • To evaluate the left/right asymmetry of PFC activity at rest using a novel Laterality Index at Rest (LIR).

Main Methods:

  • Subjects underwent a 3-minute resting-state measurement using NIRS.

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Last Updated: May 9, 2026

Qualitative and Comparative Cortical Activity Data Analyses from a Functional Near-Infrared Spectroscopy Experiment Applying Block Design
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  • Participants completed the State-Trait Anxiety Inventory (STAI) to quantify anxiety levels.
  • The Laterality Index at Rest (LIR) was calculated based on NIRS data to assess PFC activity asymmetry.

    • Main Results:

    • A significant positive correlation was found between the LIR and STAI scores in 39 subjects.
    • This indicates that greater asymmetry in PFC activity at rest is associated with higher reported anxiety.
    • The NIRS-based method successfully evaluated mental stress levels from resting-state PFC data.

    Conclusions:

    • The developed NIRS technique provides a simple and objective method for assessing mental stress.
    • The Laterality Index at Rest (LIR) effectively captures prefrontal cortex (PFC) asymmetry related to stress.
    • This approach holds potential for non-invasive stress monitoring in various clinical and research settings.