Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Carrier Transport01:21

Carrier Transport

The generation of electrical current in semiconductors is fundamentally driven by two mechanisms: drift and diffusion. These processes are essential for the functionality and performance of semiconductor-based devices.
Drift Current:
The drift of charge carriers is started by an external electric field (E). Charged particles, such as electrons and holes, experience an acceleration between collisions with lattice atoms. For electrons, this results in a drift velocity (vd) given by:
Carrier-Mediated Transport01:06

Carrier-Mediated Transport

Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Colonic Ischemia in a Patient With Pemphigus Vulgaris: Coincidence or Causation.

Cureus·2026
Same author

Machine learning to infer neurocognitive testing scores among adolescents and young adults with congenital heart disease.

Communications medicine·2026
Same author

Regional paediatric cardiac neurodevelopmental care: a survey of New England referral practices and institutional resources.

Cardiology in the young·2025
Same author

Neurodevelopmental Outcomes in Early Adolescence: The Pediatric Heart Network's Single Ventricle Reconstruction Trial.

Circulation·2025
Same author

Genome sequencing is critical for forecasting outcomes following congenital cardiac surgery.

Nature communications·2025
Same author

Non-rotation of the Intestine: A Rare and Unexpected Cause of Bowel Obstruction in an Octogenarian.

Cureus·2025
Same journal

The discovery of novel 3-nitropyridin-2-amine-based 2,3-dihydroimidazo[1,2-a]pyridin-5(1H)-one insecticides.

Pest management science·2026
Same journal

Soil-dependent variation in strigolactone signaling distance revealed by a parasitic seed germination bioassay.

Pest management science·2026
Same journal

Amplification of a metabolic shunt for elicitor detoxification: a jasmonate-exploited insect counter-defense strategy.

Pest management science·2026
Same journal

Correction to "Host tree preference and performance of the Eurasian spruce bark beetle (Ips typographus) on Scots pine".

Pest management science·2026
Same journal

Active volatiles and the odorant receptors underlying rosemary repellency to the tomato leafminer Tuta absoluta.

Pest management science·2026
Same journal

Doublesex gene influences sex differentiation and embryonic development in predatory mite Phytoseiulus persimilis.

Pest management science·2026
See all related articles

Related Experiment Video

Updated: May 9, 2026

Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery
08:22

Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery

Published on: July 18, 2019

Delivery.

Thomas A Miller1

  • 1Jefferson Science Fellow, Entomology Department, University of California, Riverside, CA, USA.

Pest Management Science
|July 16, 2013
PubMed
Summary
This summary is machine-generated.

Synthetic organic insecticides were initially welcomed but later faced opposition. Public perception shifts influenced the cautious scientific reception of genetically modified microbes, crop plants, and transgenic insects, with delivery mechanisms being a key concern.

Keywords:
genetically modified organismorganic farmingpink bollworm eradicationsterile insect techniquessystemic insecticides

More Related Videos

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
08:02

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Published on: November 7, 2013

Delivery of Proteins, Peptides or Cell-impermeable Small Molecules into Live Cells by Incubation with the Endosomolytic Reagent dfTAT
10:30

Delivery of Proteins, Peptides or Cell-impermeable Small Molecules into Live Cells by Incubation with the Endosomolytic Reagent dfTAT

Published on: September 2, 2015

Related Experiment Videos

Last Updated: May 9, 2026

Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery
08:22

Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery

Published on: July 18, 2019

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
08:02

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Published on: November 7, 2013

Delivery of Proteins, Peptides or Cell-impermeable Small Molecules into Live Cells by Incubation with the Endosomolytic Reagent dfTAT
10:30

Delivery of Proteins, Peptides or Cell-impermeable Small Molecules into Live Cells by Incubation with the Endosomolytic Reagent dfTAT

Published on: September 2, 2015

Area of Science:

  • Agricultural Science
  • Biotechnology
  • Entomology

Background:

  • Synthetic organic insecticides, initially lauded, later encountered significant public skepticism and opposition.
  • Public attitudes toward insecticides influenced the scientific community's reception of genetic engineering technologies.
  • The development of genetically modified microbes, crop plants, and transgenic insects has been met with varying degrees of acceptance and resistance.

Purpose of the Study:

  • To examine the historical progression of public and scientific attitudes towards novel pest control technologies.
  • To analyze the challenges and controversies surrounding the adoption of genetic engineering in agriculture and pest management.
  • To highlight the central role of delivery mechanisms in the debate surrounding these technologies.

Main Methods:

  • Historical review of scientific and public discourse on insecticides, genetically modified organisms, and transgenic insects.
  • Analysis of attitudinal shifts and their impact on technological development and implementation.
  • Identification of recurring themes and concerns, particularly regarding the methods of technology delivery.

Main Results:

  • A pattern of initial enthusiasm followed by skepticism and opposition characterizes the introduction of new pest control technologies.
  • Public perception, influenced by factors such as the perceived risks and benefits of insecticides, has significantly shaped scientific caution and resistance.
  • Concerns over delivery mechanisms consistently emerge as a focal point in the debate surrounding genetically engineered solutions.

Conclusions:

  • The development and adoption of innovative pest control strategies, including transgenic approaches, are complex processes influenced by public perception and scientific caution.
  • Understanding and addressing concerns related to delivery mechanisms is crucial for the successful integration of future pest management technologies.
  • The historical trajectory suggests a need for transparent communication and engagement to navigate the challenges posed by novel biotechnologies in agriculture.