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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

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Related Experiment Video

Updated: May 9, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Altered structure-function relations of semantic processing in youths with high-functioning autism: a combined

Yu-Chun Lo1, Tai-Li Chou, Li-Ying Fan

  • 1Department of Psychiatry, National Taiwan University College of Medicine, Taipei, Taiwan; Center for Optoelectronic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.

Autism Research : Official Journal of the International Society for Autism Research
|July 16, 2013
PubMed
Summary

Autism is linked to altered brain pathways crucial for language processing. This study reveals unique structure-function relationships in the autistic brain, impacting language and communication abilities.

Keywords:
autismdiffusion spectrum imagingdual stream modelfunctional MRItractography

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Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
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Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

A Semantic Priming Event-related Potential (ERP) Task to Study Lexico-semantic and Visuo-semantic Processing in Autism Spectrum Disorder
08:17

A Semantic Priming Event-related Potential (ERP) Task to Study Lexico-semantic and Visuo-semantic Processing in Autism Spectrum Disorder

Published on: April 12, 2018

Related Experiment Videos

Last Updated: May 9, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

A Semantic Priming Event-related Potential (ERP) Task to Study Lexico-semantic and Visuo-semantic Processing in Autism Spectrum Disorder
08:17

A Semantic Priming Event-related Potential (ERP) Task to Study Lexico-semantic and Visuo-semantic Processing in Autism Spectrum Disorder

Published on: April 12, 2018

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Linguistics

Background:

  • Autism Spectrum Disorder (ASD) is characterized by core deficits in language and communication.
  • The neural underpinnings of autistic language impairment, particularly within the dual stream language network, are not fully understood.
  • Investigating the interplay between brain structure and function is key to understanding these deficits.

Purpose of the Study:

  • To investigate alterations in the dual stream language network in youths with autism.
  • To examine the relationship between microstructural integrity and functional activation within language pathways.
  • To compare these structure-function relationships between autistic and typically developing individuals.

Main Methods:

  • Recruited 20 male youths with autism and 20 typically developing (TD) controls.
  • Utilized diffusion spectrum imaging (DSI) to assess microstructural integrity of left dorsal and ventral language pathways.
  • Employed functional magnetic resonance imaging (fMRI) during a semantic task to measure functional activation in connected brain regions.

Main Results:

  • Youths with autism exhibited poorer language function and reduced activation in key language network regions compared to TD youths.
  • TD participants showed a correlation between left dorsal functional activation and left ventral pathway integrity.
  • Autistic participants displayed a reversed correlation: left ventral activation linked to left dorsal pathway integrity, alongside verbal comprehension deficits correlated with left ventral pathway integrity.

Conclusions:

  • Altered structure-function relationships within the dual stream language network are evident in autism.
  • These neurobiological differences may underlie the semantic processing deficits observed in autism.
  • Findings suggest distinct neural mechanisms support language in autistic individuals, highlighting potential therapeutic targets.