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Updated: May 9, 2026

A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats
Published on: November 7, 2017
A 0.09 μW low power front-end biopotential amplifier for biosignal recording
Yuhwai Tseng1, Yingchieh Ho, Shuoting Kao
1Electrical Engineering Department and Institute of Electrical Control Engineering, National Chiao Tung University, Hsinchu 300, Taiwan. yuhwaitseng@mail.nctu.edu.tw
Abstract:
This work presents a biopotential front-end amplifier in which the MOS transistors are biased in subthreshold region with a supply voltage and current of 0.4-0.8 V and 0.23-1.86 μA, respectively, to reduce the system power. Flicker noise is then removed using a chopping technique, and differential interference produced by electrode impedance imbalance is suppressed using a Gm-C filter. Additionally, the circuit is fabricated using TSMC 0.18 μm CMOS technology with a core area of 0.77 × 0.36 mm². With a minimum supply voltage of 0.4 V, the measured SNR and power consumption of the proposed IC chip are 54.1 dB and 0.09μW, respectively.
