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Development and in vivo Demonstration of CMOS-Based Multichip Retinal Stimulator With Simultaneous Multisite

T Tokuda, Y Takeuchi, Y Sagawa

IEEE Transactions on Biomedical Circuits and Systems

|July 16, 2013

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Researchers developed a flexible neural stimulator using complementary metal-oxide semiconductor (CMOS) technology for retinal prostheses. This device enables simultaneous multisite stimulation, confirmed through successful in vivo testing on rabbit retinas.

Area of Science:

Biomedical Engineering
Neuroscience
Materials Science

Background:

Retinal prostheses aim to restore vision by electrically stimulating remaining retinal neurons.
Current devices face challenges in achieving high-resolution, simultaneous stimulation of multiple sites.
Flexible electronics offer potential for improved biocompatibility and integration with neural tissue.

Purpose of the Study:

To develop and evaluate a novel complementary metal-oxide semiconductor (CMOS)-based multichip flexible neural stimulator for retinal prostheses.
To demonstrate the capability of simultaneous multisite stimulation for enhanced visual signal processing.
To validate the device's performance and functionality through in vivo testing.

Main Methods:

A multichip flexible neural stimulator was designed and fabricated using CMOS technology.

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An on-chip stimulation generator was integrated into the core 'unit chip'.

New device structures and packaging processes were developed for flexibility and biocompatibility.

In vivo retinal stimulation experiments were conducted on rabbit retinas.

Main Results:

The CMOS circuitry performance was successfully characterized.
The developed device structure and packaging process proved effective.
Successful in vivo retinal stimulation was achieved in rabbits.
The simultaneous multisite stimulation functionality was confirmed in the animal model.

Conclusions:

A functional CMOS-based multichip flexible neural stimulator for retinal prostheses was successfully developed.
The device demonstrated the critical capability for simultaneous multisite stimulation.
In vivo validation confirmed the potential of this technology for vision restoration applications.