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[Serum levels of IL-10 and IL-35 in Yusho patients]

Yuta Koike1, Yutaka Kuwatsuka, Kazuhiro Shimizu

  • 1Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital.

Fukuoka Igaku Zasshi = Hukuoka Acta Medica
|July 18, 2013
PubMed

We thought that dioxin and dioxin-like compound receptor AhR expressed on the surface of regulatory T (Treg) cells and Th17 cells could regulate immunological functions in the Yusho patients. In the present study, we measured Treg cell related cytokines IL-10 and IL-35 in the Yusho patients. Serum levels of IL-10 were higher, but not significant (p = 0.06), and serum levels of IL-35 were increased (p = 0.006) in comparison with healthy controls. These results imply Treg cell activation in the Yusho patients.

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