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Published on: July 11, 2014
Improvement of measurement method for hydroxylated polychlorinated biphenyls (OH-PCBs) in blood samples using
Kazuhiro Tobiishi1, Shigeru Suzuki, Takashi Todaka
1Fukuoka Institute of Health and Environmental Sciences, 39 Mukaizano, Dazaifu, Fukuoka, Japan. tobiishi@fihes.pref.fukuoka.jp
Abstract:
Hydroxylated polychlorinated biphenyls (OH-PCBs) are well known as metabolites of PCBs in the human body. We improved a measurement method for OH-PCBs in blood samples using LC/MS/MS. A new 2 microm particle column was used, and the analytical conditions for the LC/MS/MS measurements were optimized. The improved method is more sensitive than the conventional method for 5g blood samples. And, this method is effective at determining the concentrations of OH-PCBs, PCBs and dioxins from the same sample without special treatment of the sample such as derivatization.
