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Updated: May 9, 2026

Assays for the Identification of Novel Antivirals against Bluetongue Virus
Published on: October 11, 2013
Synthesis and biological evaluation of novel antiviral agents as protein-protein interaction inhibitors
Stefania Ferro1, Laura De Luca, Francesca Morreale
1Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, Università di Messina , Messina , Italy and.
Abstract:
In continuation of our research efforts toward the identification and optimization for novel inhibitors of interaction between human immunodeficiency virus type 1 integrase and cellular cofactor LEDGF/p75, we designed and synthesized a new series of 4-benzylindole derivatives. Most of the title compounds proved to be able to block this protein-protein interaction (PPI), with a percentage ranging from 30% to 90% at 100 µM. The most promising derivative was compound 10b showing IC50 value of 6.41 µM. The main structure-activity relationships (SAR) are discussed and rationalized by docking studies.
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