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Published on: August 9, 2022
Solid dispersion in pharmaceutical drug development: from basics to clinical applications.
Punit Bhatnagar, Vinod Dhote, Suresh Chandra Mahajan
1Department of Pharmaceutics, College of Pharmacy, IPS Academy, Indore (M.P.) India. dineshdops@yahoo.com.
Current Drug Delivery
|July 18, 2013
Summary
Solid dispersion (SD) enhances drug solubility and bioavailability by reducing particle size. This review covers SD
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery
- Formulation Development
Background:
- Drug solubility is a major hurdle in novel drug discovery and formulation.
- Poor water solubility limits the bioavailability of many potential therapeutics.
- Various strategies exist to improve drug solubility, with solid dispersion being a key approach.
Purpose of the Study:
- To provide a comprehensive review of solid dispersion technology for enhancing drug solubility.
- To explore the historical development, classification, and mechanisms of solid dispersion.
- To discuss manufacturing processes, recent breakthroughs, and pharmaceutical applications of solid dispersion.
Main Methods:
- Literature review of solid dispersion techniques and applications.
- Analysis of historical milestones and classification of solid dispersion methods.
- Examination of mechanisms for solubility enhancement and commercial manufacturing processes.
Main Results:
- Solid dispersion significantly improves drug solubility and bioavailability by creating molecular dispersions.
- The review details various solid dispersion manufacturing techniques suitable for commercial scale.
- Applications in anti-cancer and anti-retroviral drug formulations are highlighted, showcasing versatile utility.
Conclusions:
- Solid dispersion is a highly promising strategy for overcoming poor drug solubility challenges.
- Understanding formulation characteristics is crucial for successful solid dispersion development.
- This technology offers significant translational implications for developing effective drug formulations.
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