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Updated: May 9, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
Novel antimicrobial metabolites produced by Sika deer-associated Actinomyces sp. JN411010
Yujiao Tang1, Yanmei Wang, Zhaohui Wang
1a China-Korea Joint Institute for Animal Science of Jilin Province , Changchun , 130600 , P.R. China.
Abstract:
Three novel metabolites (1, 5 and 10) were isolated from a 25-L fermentation broth of Actinomyces sp. JN411010 together with 11 related compounds. Their structures were determined on the basis of 1D and 2D NMR, as well as HR-ESI-MS spectroscopic data analyses. Compounds 1-2, 5-8 and 10 displayed moderate antimicrobial activities against Gram-positive and Gram-negative bacteria. Biosynthetic pathway of 5 and 10 was proposed to be catalysed by polyketide and non-ribosomal peptide gene clusters, respectively.
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