A dual role for sirtuin 1 in tumorigenesis
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Updated: May 9, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
Published on: February 27, 2016
Yujiang Fang, Michael B Nicholl1
1Department of Surgery, University of Missouri, One Hospital Drive, MC520E, DC116.94, Columbia, MO 65212, USA. nichollm@health.missouri.edu.
Abstract:
Sirtuin 1 (SIRT1) is an NAD+-dependent histone deacetylase which regulates many normal physiological and pathological processes. In addition to its place in cellular energy metabolism, increasing evidence shows a role for SIRT1 in tumorigenesis, wherein it can function as either a tumor promoter or suppressor. Its function in malignancy varies with concentration, cellular location, temporal and spatial distribution, and regulation by upstream and downstream factors. In this mini-review, we present the existing data which implicates SIRT1 in tumorigenesis.
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