Related Experiment Video
Updated: May 9, 2026

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures
Published on: January 19, 2019
Amphiphilic oligoethyleneimine-β-cyclodextrin "click" clusters for enhanced DNA delivery
Álvaro Martínez1, Céline Bienvenu, José L Jiménez Blanco
1Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Profesor García González 1, E-41012 Sevilla, Spain.
Abstract:
Monodisperse amphiphilic oligoethyleneimine (OEI)-β-cyclodextrin (βCD) clusters have been prepared, and their potential as gene delivery systems has been evaluated in comparison with a nonamphiphilic congener. The general prototype incorporates tetraethyleneimine segments linked to the primary rim of βCD through either triazolyl or thioureidocysteaminyl connectors. Transfection efficiency data for the corresponding CD:pDNA nanocomplexes (CDplexes) in BNL-CL2 murine hepatocytes evidenced the strong beneficial effect of facial amphiphilicity.
Related Concept Videos
DNA Packaging
Site-Targeted Drug Delivery Systems: Polymeric Carriers

