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[Preformulation study of controlled release nitrofurantoin preparations. 2].
S Marton1, Nguyen Thi Minh Tam, I Antal
1SOTE Gyógyszerészeti Intézet, Budapest, Högyes.
Acta Pharmaceutica Hungarica
|May 1, 1990
Summary
Controlled-release nitrofurantoin formulations were optimized for enhanced bioavailability. Products coated with Eudragit L 100-55 demonstrated superior active principle release and in vitro absorption.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Previous studies detailed the preparation and stability of controlled-release nitrofurantoin.
- Optimizing drug release and absorption is crucial for therapeutic efficacy.
Purpose of the Study:
- To investigate the in vitro release and absorption of nitrofurantoin from novel controlled-release formulations.
- To identify the most suitable formulation for optimal drug bioavailability.
Main Methods:
- In vitro release studies using the rotating basket method and Sartorius Dissolution tester.
- In vitro absorption studies using the Sartorius Membrane transport tester.
- Evaluation of active principle and coated drug absorption.
Main Results:
- Formulations coated with Eudragit L 100-55 exhibited favorable active principle release profiles.
- These Eudragit L 100-55 coated products showed enhanced in vitro absorption.
- Both compressed and capsuled forms demonstrated suitability.
Conclusions:
- Eudragit L 100-55 is a suitable coating material for controlled-release nitrofurantoin.
- Optimized release and absorption suggest potential for improved bioavailability.
- Controlled drug release and absorption are achievable with the developed formulations.