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Cimetidine increases the pancreatic response to histamine
J A Pariente1, L P Francis, G M Salido
1Department of Physiology, Faculty of Veterinary Sc., University of Extremadura, Cáceres, Spain.
Agents and Actions
|June 1, 1990
Summary
Histamine stimulates pancreatic enzyme secretion in rabbits via H1 receptors. Blocking H2 receptors with cimetidine potentiated this effect, suggesting a complex histamine interaction in pancreatic function.
Area of Science:
- Gastroenterology
- Pharmacology
- Physiology
Background:
- Histamine is known to influence various physiological processes.
- The specific role of histamine receptors in pancreatic exocrine secretion requires further elucidation.
Purpose of the Study:
- To investigate the effects of histamine on basal pancreatic exocrine secretion.
- To determine the receptor subtypes involved in histamine-mediated pancreatic stimulation.
Main Methods:
- Anesthetized rabbits with acute pancreatic cannulation were used.
- Intravenous administration of histamine alone and in combination with cimetidine (H2 antagonist) was performed.
- Pancreatic enzyme secretion was measured.
Main Results:
- Histamine administration alone increased pancreatic enzyme secretion.
- A significantly greater stimulatory effect on pancreatic secretion was observed when histamine was given with cimetidine.
- These findings suggest a role for H1 receptors in mediating histamine's effect.
Conclusions:
- Histamine stimulates pancreatic exocrine secretion in rabbits.
- The stimulatory effect of histamine on the rabbit pancreas is primarily mediated by H1 receptors.
- H2 receptor blockade potentiates histamine-induced pancreatic secretion.