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Correlation between endodontic broken instrument and nickel level in urine
Mohammad Ali Saghiri1, Nader Sheibani, Franklin Garcia-Godoy
1Department of Ophthalmology and Visual Sciences, University of Wisconsin, School of Medicine and Public Health, Madison, WI, USA. saghiri@gmail.com
Biological Trace Element Research
|July 18, 2013
Summary
Elevated nickel levels in urine may indicate a separated endodontic instrument in the dental canal. However, the duration the instrument fragments remain does not correlate with increased nickel levels.
Area of Science:
- Dental materials science
- Analytical chemistry
- Toxicology
Background:
- Separated endodontic instruments can remain in the root canal.
- Nickel (Ni) is a component of many endodontic instruments.
- The potential systemic release and detection of Ni from these fragments is not fully understood.
Purpose of the Study:
- To investigate the correlation between separated endodontic instruments and urinary nickel levels.
- To determine if the duration of instrument presence influences nickel levels.
- To assess the relationship between patient age and urinary nickel in the context of endodontic fragments.
Main Methods:
- Urine samples collected from patients with and without separated endodontic instruments.
- Nickel levels measured using electrothermal atomic absorption spectrometry.
- Statistical analysis including t-tests, Pearson's correlation, and linear regression (P < 0.05).
Main Results:
- A significant difference in urinary nickel levels was observed between the endodontic and control groups (P < 0.05).
- No correlation found between urinary nickel and the time period of the broken instrument.
- A positive correlation was noted between urinary nickel levels and participant age within the experimental group.
Conclusions:
- Increased urinary nickel may be associated with the presence of separated endodontic instruments.
- The aging of retained endodontic instrument fragments does not appear to significantly impact urinary nickel levels over time.
- Further research is needed to understand the long-term implications of nickel release from endodontic fragments.
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