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Updated: May 9, 2026

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
Published on: February 1, 2022
Chemically synthesized graphene for electrochemical biosensing
Mukesh Mishra1, Subbiah Alwarappan, Rakesh K Joshi
1School of Physical Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
Chemically synthesized graphene offers a new, high-yield route for creating electrochemical biosensors. These graphene-based sensors demonstrate excellent stability for detecting neurotransmitters like dopamine and serotonin.
Area of Science:
- Materials Science
- Electrochemistry
- Nanotechnology
Background:
- Graphene's unique properties make it promising for electrochemical biosensing.
- Developing efficient synthesis methods for graphene is crucial for its practical application.
- Existing methods may have limitations in yield or scalability.
Purpose of the Study:
- To report a novel chemical synthesis method for graphene.
- To evaluate the electrochemical performance of synthesized graphene for biosensing.
- To assess the stability of graphene-based electrochemical biosensors.
Main Methods:
- Chemical synthesis of graphene with a focus on yield.
- Electrochemical characterization using two redox materials.
- Detection of neurotransmitters (dopamine and serotonin) using graphene electrodes.
- Stability testing of electrodes over 45 days.
Main Results:
- Successful synthesis of graphene via a new chemical route with good yield.
- Demonstrated suitability of synthesized graphene for electrochemical biosensing.
- Graphene electrodes showed high stability, with only a minor signal decrease (20% +/- 5%) after 45 days of storage.
- Effective detection of dopamine and serotonin was achieved.
Conclusions:
- The developed chemical method provides a viable route for graphene synthesis.
- Chemically synthesized graphene exhibits high stability and performance for electrochemical biosensing applications.
- This work highlights the potential of graphene in neurotransmitter detection and stable biosensor development.
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