Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Preparation and Reactions of Sulfides02:26

Preparation and Reactions of Sulfides

Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting the NAD<sup>+</sup>-PARP1-XRCC1 axis in ALS.

Trends in molecular medicine·2026
Same author

A nanovaccine induces durable and functional MUC4-targeted T cell responses against pancreatic cancer.

Acta biomaterialia·2026
Same author

Peripheral vaccination-induced brain-resident memory CD8+ T cells durably protect mice against intracranial malignancy.

The Journal of clinical investigation·2026
Same author

The Versatile Role of GDF5 in Chondrogenic Progenitor Cell-mediated Cartilage Regeneration via a Hyaluronic Acid-fibrin IPN Hydrogel Platform.

Pharmaceutical research·2026
Same author

Quantitative Proteomic Profiling of Bronchoalveolar Lavage-Derived Extracellular Vesicles in a Murine Asthma Model.

Chemical research in toxicology·2026
Same author

mRNA vaccination overcomes haemozoin-mediated impairment of whole-parasite malaria vaccines in mice.

Nature microbiology·2026
Same journal

Rationally engineered essential oil-loaded nanocarriers for acne vulgaris: integrating multiscale molecular modeling, machine learning, and response surface optimization.

Journal of microencapsulation·2026
Same journal

Retinyl palmitate-loaded nanostructured lipid carriers prepared by the phase inversion temperature method: Physicochemical properties, <i>in vitro</i> skin permeation, and occlusion ability.

Journal of microencapsulation·2026
Same journal

Green synthesis of silver nanoparticles using <i>Swertia chirayita</i> and their antioxidant and anticancer potential.

Journal of microencapsulation·2026
Same journal

Management of coronary artery disease via simvastatin-loaded novasomes.

Journal of microencapsulation·2026
Same journal

Phyto-engineered CuO nanoparticles from gum <i>Eucalyptus camaldulensis</i>: a GC-MS, molecular docking, and bioactivity study.

Journal of microencapsulation·2026
Same journal

Development and optimization of gallic acid-enriched nanostructured lipid carriers for the amelioration of rheumatic inflammation: <i>in-vitro</i> and <i>in-vivo</i> study.

Journal of microencapsulation·2026
See all related articles

Related Experiment Video

Updated: May 9, 2026

Synthesis of Ligand-free CdS Nanoparticles within a Sulfur Copolymer Matrix
09:15

Synthesis of Ligand-free CdS Nanoparticles within a Sulfur Copolymer Matrix

Published on: May 1, 2016

Microparticles prepared from sulfenamide-based polymers.

Sheetal R D'Mello1, Jun Yoo, Ned B Bowden

  • 1Department of Pharmaceutical Sciences & Experimental Therapeutics, College of Pharmacy, University of Iowa , Iowa City, IA , USA and.

Journal of Microencapsulation
|July 19, 2013
PubMed
Summary
This summary is machine-generated.

Polysulfenamides (PSN) were developed into microparticles for controlled drug delivery. These biodegradable and biocompatible PSN microparticles show promising cellular uptake and drug release characteristics.

More Related Videos

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Related Experiment Videos

Last Updated: May 9, 2026

Synthesis of Ligand-free CdS Nanoparticles within a Sulfur Copolymer Matrix
09:15

Synthesis of Ligand-free CdS Nanoparticles within a Sulfur Copolymer Matrix

Published on: May 1, 2016

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomedical Engineering

Background:

  • Polysulfenamides (PSN), characterized by a sulfur-nitrogen (SN) linkage, are a novel class of biodegradable and biocompatible polymers first reported in 2012.
  • Their synthesis and promising medicinal properties have spurred interest in their application for advanced materials.

Purpose of the Study:

  • To develop microparticles using polysulfenamide as a matrix for controlled drug delivery.
  • To investigate the encapsulation and release kinetics of a model hydrophilic compound within these microparticles.

Main Methods:

  • Microparticles were fabricated using a water-in-oil-in-water double-emulsion solvent-evaporation technique.
  • FITC-dextran was employed as a model hydrophilic drug for loading studies.
  • Scanning electron microscopy (SEM), zetasizer analysis, and confocal laser scanning microscopy (CLSM) were utilized for characterization and cellular uptake studies.

Main Results:

  • Optimized PSN microparticles exhibited smooth surfaces, spherical morphology, and low polydispersity.
  • Zetasizer analysis revealed a net negative surface charge of -23 mV.
  • Encapsulation efficiency and drug loading were influenced by drug molecular weight, PSN concentration, and emulsion phase volumes.
  • FITC-dextran release showed an initial burst followed by sustained release.
  • CLSM confirmed cellular uptake and intracellular localization (cytoplasm and nucleus) of PSN microparticles.

Conclusions:

  • Polysulfenamide microparticles are a viable matrix for controlled drug delivery systems.
  • The characteristics of PSN microparticles, including morphology, surface charge, and drug release profile, can be tuned through formulation.
  • PSN microparticles demonstrate effective cellular uptake, indicating potential for intracellular drug delivery applications.