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Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib
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[Two cases of recurrent GIST successfully treated with imatinib mesylate at 100mg/day]

Norihisa Hanada1, Kousei Kawata, Shigeki Okamura

  • 1Dept. of Surgery, Izumi General Medical Center, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|July 19, 2013
PubMed

Case 1: Recurrent tumors from gastric GIST in the liver and the abdominal wall showed partial response with 200mg/day imatinib and maintained partial response at 100mg/day. Case 2: Metastatic liver tumors from the jejunal GIST showed partial response with 200mg/day imatinib. The tumors have been enlarged for interruption of imatinib administration, however, re- treatment with imatinib resulted in partial response again and kept partial response at 100mg/day of imatinib. The two cases seldom encountered adverse events at 100mg/day of imatinib. There are some cases successfully treated with low-dose imatinib mesylate for recurrent GIST.

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