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Updated: May 9, 2026

09:09
Visualizing Diffusional Dynamics of Gold Nanorods on Cell Membrane using Single Nanoparticle Darkfield Microscopy
Published on: March 5, 2021
Detection of DNA induced gold nanoparticle aggregation with dark field imaging
Tong Bu1, Tamotsu Zako, Masahiro Fujita
1Department of Advanced Materials Science, School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 227-8561, Japan.
Abstract:
Dark field imaging was employed to visualize and quantify complementary DNA-induced gold nanoparticle aggregation at the single-particle level, with a detection limit of 100 fM DNA, which allows the highly sensitive detection of single nucleotide polymorphisms (SNPs). Results suggested that the aggregation process is consistent with the cluster-cluster model.

