[Histometric research on cor pulmonale in chronic nonspecific lung diseases]

Micrometric parameters of lungs and the right ventricle myocardium under the pulmonary heart compensation and decompensation were studied. Correlative and information analysis of parameters at various stages of the pulmonary heart formation in chronic non-specific pulmonary diseases in 14 patients dying at the age of 48 to 80 years is performed. Morphometric analysis allowed to distinguish micrometric signs of the pulmonary heart compensation and decompensation. Information analysis of the pulmonary heart parameters established the thickness of cardiomyocytes and transversal diameter of their nuclei to be the most informative indexes. Correlation analysis revealed the enhancement of the parameters links, in proportion with the development of the pulmonary heart decompensation. The changes observed reflect a structural-functional myocardium restructuring and indicate an energy deficiency of the right ventricle cardiomyocytes.