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Age-related changes in glutathione synthesis in the eye lens
J V Ferrer1, E Gascó, J Sastre
1Departamento de Fisiología, Facultad Medicina, Valencia, Spain.
The Biochemical Journal
|July 15, 1990
Abstract:
Eye lenses from young rats or mice synthesize GSH from methionine or N-acetylcysteine. However, lenses from old animals do not synthesize GSH from methionine. This is due to the absence of cystathionase activity in old lenses. GSH monoethyl ester, but not free GSH, increases GSH content and protects the lens against experimental oxidative stress. The importance of these results in the prevention of cataractogenesis is discussed.