Related Experiment Video
Updated: May 9, 2026
02:09
Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
Published on: April 12, 2024
Positron emission tomography in chronic obstructive pulmonary disease
Poul Henning Madsen1, Søren Hess, Poul Flemming Høilund-Carlsen
1Sygehus Lillebælt, Medicinsk Afdeling Dronningensgade 97, Denmark. phmadsen@dadlnet.dk
Hellenic Journal of Nuclear Medicine
|July 19, 2013
Summary
Positron emission tomography with (18)F-fluorodeoxyglucose ((18)F-FDG-PET) shows promise in managing chronic obstructive pulmonary disease (COPD). This technique may aid in diagnosis, inflammation assessment, and prognosis for COPD patients.
Area of Science:
- Medical Imaging
- Pulmonology
- Nuclear Medicine
Background:
- Chronic obstructive pulmonary disease (COPD) presents diagnostic and management challenges.
- Current diagnostic tools may not fully capture disease complexity or inflammatory status.
Purpose of the Study:
- To systematically review the literature on the application of (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) in COPD management.
- To assess the potential utility of (18)F-FDG-PET in various aspects of COPD care.
Main Methods:
- Comprehensive literature search of PubMed, EMBASE, and Cochrane Library.
- Inclusion of studies using MESH terms related to COPD and positron emission tomography.
- Systematic review and synthesis of findings from identified relevant reports.
Main Results:
- Seven relevant reports were identified from an initial search.
- (18)F-FDG-PET may differentiate COPD from other conditions like chronic asthma and alpha-1-antitrypsin deficiency.
- Potential applications include measuring inflammation, quantifying respiratory muscle activity, and diagnosing cor pulmonale.
Conclusions:
- The existing literature suggests (18)F-FDG-PET holds promise for COPD diagnosis and management.
- Further research is warranted to fully establish the role of (18)F-FDG-PET in clinical practice for COPD.
- This imaging modality could offer new insights into disease mechanisms and patient stratification.
More Related Videos
Related Concept Videos
01:29Positron Emission Tomography
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
01:23Chronic Obstructive Pulmonary Disease II: Emphysema
Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
01:24Chronic Obstructive Pulmonary Disease
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.