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Updated: May 9, 2026
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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
Group 2 innate lymphoid cells in lung inflammation.
Bobby W S Li1, Rudi W Hendriks
1Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, the Netherlands.
Immunology
|July 20, 2013
Summary
Group 2 innate lymphoid cells (ILC2) are a critical innate source of type 2 cytokines, challenging the traditional view of T helper 2 (Th2) cells in allergic asthma. This review highlights ILC2
Area of Science:
- Immunology
- Allergy Research
- Respiratory Medicine
Background:
- Allergic asthma pathogenesis traditionally involves T helper 2 (Th2) cells and their cytokines (IL-4, IL-5, IL-13).
- Recent discoveries identify group 2 innate lymphoid cells (ILC2) as a significant innate source of type 2 cytokines.
- Epithelial cell-derived cytokines like IL-25 and IL-33 activate ILC2 and are implicated in asthma initiation.
Purpose of the Study:
- To review recent studies on the role of ILC2 in lung inflammation.
- To emphasize the involvement of ILC2 in allergen-induced asthma.
- To discuss the emerging understanding of ILC2 in asthma pathogenesis.
Main Methods:
- Literature review of recent studies.
- Analysis of research on ILC2 function in respiratory inflammation.
- Focus on ILC2 involvement in allergic asthma models.
Main Results:
- ILC2 are a critical innate source of type 2 cytokines (IL-4, IL-5, IL-13).
- ILC2 activation by IL-25 and IL-33 plays a role in initiating asthma.
- Evidence supports a significant role for ILC2 in allergen-induced lung inflammation.
Conclusions:
- ILC2 represent a key cellular player in type 2 inflammation in the lung.
- The role of ILC2 in asthma pathogenesis is increasingly recognized.
- Further research into ILC2 function may reveal new therapeutic targets for allergic asthma.
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