Related Experiment Video

Updated: May 9, 2026

Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay
11:49

Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay

Published on: July 28, 2014

Orphan G protein receptor GPR55 as an emerging target in cancer therapy and management

Dinorah Leyva-Illades1, Sharon Demorrow

  • 1Digestive Disease Research Center, Scott and White Hospital, Temple, TX, USA ; Department of Internal MedicineTexas A&M Health Science Center, Temple, TX, USA ; Research Service, Central Texas Veterans Health Care System, Temple, TX, USA.

Cancer Management and Research
|July 23, 2013
PubMed

Insights

This review covers G protein-coupled receptors (GPCRs) and their physiological roles. It highlights the GPR55 receptor

Area of Science:

  • Pharmacology
  • Cell Biology
  • Oncology

Background:

  • G protein-coupled receptors (GPCRs) are crucial cell surface receptors involved in numerous physiological processes.
  • Understanding GPCRs is vital for comprehending cellular signaling and disease mechanisms.

Purpose of the Study:

  • To provide a comprehensive overview of GPCR characteristics and their physiological functions.
  • To elucidate the known physiological and pathophysiological roles of the orphan GPCR, GPR55.
  • To explore the potential of GPR55 as a therapeutic target in cancer treatment.

Main Methods:

  • Literature review of GPCR general characteristics.
  • Analysis of existing research on GPR55's physiological and pathophysiological functions.
  • Exploration of GPR55's therapeutic potential in oncology.

Main Results:

  • GPCRs regulate a wide spectrum of cellular activities.
  • GPR55 is implicated in various physiological and pathophysiological conditions.
  • GPR55 presents a promising target for novel cancer therapies.

Conclusions:

  • GPCRs are fundamental to cellular function and homeostasis.
  • GPR55's multifaceted roles warrant further investigation for therapeutic applications.
  • Targeting GPR55 may offer new strategies for combating diverse types of cancer.
Keywords:
GPCRGPR55cancerendocannabinoids

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