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Chronic Pharyngitis01:23

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
Tonsillitis I: Introduction01:30

Tonsillitis I: Introduction

Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...

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Related Experiment Video

Updated: May 9, 2026

Endaural Endoscopic Atticoantrotomy (Retrograde Mastoidectomy) using a Constant Suction Bone-drilling Technique
07:06

Endaural Endoscopic Atticoantrotomy (Retrograde Mastoidectomy) using a Constant Suction Bone-drilling Technique

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Chronic suppurative otitis media.

Peter Morris1

  • 1Menzies School of Health, Australia.

BMJ Clinical Evidence
|July 23, 2013
PubMed
Summary
This summary is machine-generated.

This systematic review evaluates treatments for chronic suppurative otitis media (CSOM) and cholesteatoma. It found evidence on various interventions, including antibiotics and surgery, to inform clinical practice for these common ear conditions.

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Area of Science:

  • Otolaryngology
  • Evidence-based medicine
  • Systematic reviews

Background:

  • Chronic suppurative otitis media (CSOM) is a prevalent condition causing hearing loss and disability.
  • CSOM can lead to severe complications like intracranial infections and acute mastoiditis, particularly in developing regions.

Purpose of the Study:

  • To systematically review and synthesize evidence on the effectiveness and safety of treatments for chronic suppurative otitis media (CSOM) in adults and children.
  • To evaluate treatments for cholesteatoma in both adult and pediatric populations.

Main Methods:

  • Conducted a systematic literature review up to May 2010, searching major databases (Medline, Embase, Cochrane Library).
  • Included 51 systematic reviews, randomized controlled trials (RCTs), and observational studies.
  • Incorporated safety alerts from regulatory agencies (FDA, MHRA).
  • Utilized GRADE methodology for evaluating evidence quality.

Main Results:

  • Identified and analyzed data from 51 relevant studies.
  • Evaluated the quality of evidence for various interventions using the GRADE system.

Conclusions:

  • Presents findings on the effectiveness and safety of interventions for CSOM and cholesteatoma.
  • Key interventions reviewed include topical ear cleansing, surgery for cholesteatoma, systemic and topical antibiotics, topical corticosteroids, and tympanoplasty.