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In Vesiculo Synthesis of Peptide Membrane Precursors for Autonomous Vesicle Growth
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Acyl transfer from membrane lipids to peptides is a generic process.

Robert H Dods1, Burkhard Bechinger, Jackie A Mosely

  • 1Department of Chemistry, Biophysical Sciences Institute, Durham University, Durham DH1 3LE, United Kingdom.

Journal of Molecular Biology
|July 23, 2013
PubMed
Summary

Acyl transfer from phospholipids to membrane-active peptides is a common process, even with diverse lipid compositions. This suggests phospholipid membranes are not chemically inert towards peptides and proteins.

Keywords:
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine1-stearoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine1-stearoyl-2-linoleoyl-sn-glycero-3-phosphoglycerol1-stearoyl-2-linoleoyl-sn-glycero-3-phosphoserineFTICRFourier transform ion cyclotron resonanceLCMSP:LPCPOPCSLPESLPGSLPSTFAacylationlipidationliquid chromatographymass spectrometrymelittinmembranepeptide-to-lipid ratiophosphatidylcholinephospholipidtrifluoroacetic acid

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