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Updated: May 9, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
Published on: August 6, 2015
Characterization of heterotopic ossification in burn patients
Abelardo Medina1, Heather Shankowsky, Bohdan Savaryn
1From the *Wound Healing Research Group, Division of Plastic and Reconstructive Surgery, †Division of Critical Care Medicine, and ‡Firefighters' Burn Treatment Unit, Department of Surgery, University of Alberta, Edmonton, Canada.
Abstract:
Heterotopic ossification (HO) is a clinical condition of ectopic bone formation in soft tissue. This clinical entity has been associated with genetic disorders, traumatic injuries, and musculoskeletal surgeries. In this regard, functional impairments secondary to scar contractures seen in burn injuries may be exacerbated with underlying HO. The appropriate prevention or management of this complication is crucial to optimize outcome in burn patients. This clinical study reviews the incidence of HO in our burned patients, diagnostic methods, therapeutic approaches including surgical timing and techniques.
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