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Published on: December 10, 2015
The nuclear envelope LEM-domain protein emerin
Jason M Berk1, Kathryn E Tifft, Katherine L Wilson
1Department of Cell Biology; Johns Hopkins University School of Medicine; Baltimore, MD USA.
Nucleus (Austin, Tex.)
|July 23, 2013
Summary
Emerin, a nuclear membrane protein, plays key roles in genome regulation and cellular processes. Further research into emerin and its family is crucial for understanding their genomic influence.
Area of Science:
- Molecular Biology
- Cell Biology
- Genomics
Background:
- Emerin is a well-characterized LEM-domain protein found in the nuclear membrane.
- Extensive knowledge exists regarding emerin's biochemistry, partners, functions, localization, and post-translational regulation.
- Emerin is linked to human diseases and plays roles in development.
Purpose of the Study:
- To review the known functions and emerging roles of emerin.
- To highlight the significance of emerin in nuclear structure and genome regulation.
- To identify open questions critical for understanding emerin's influence on the genome.
Main Methods:
- Literature review and synthesis of existing research on emerin.
- Analysis of emerin's involvement in various cellular processes.
- Identification of knowledge gaps and future research directions.
Main Results:
- Emerin is involved in nuclear lamina structure and chromatin tethering.
- Emerin influences gene regulation, mitosis, nuclear assembly, and signaling.
- Emerin plays a role in mechano-transduction and embryonic development.
Conclusions:
- Emerin is a multifaceted nuclear protein with critical roles in genome organization and cellular function.
- Understanding emerin's interactions and regulatory mechanisms is essential for advancing cell and developmental biology.
- Further exploration of emerin and its protein family will illuminate their impact on genomic stability and function.
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