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Updated: May 9, 2026

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Total synthesis of the proposed structure of didemnaketal B
Haruhiko Fuwa1, Kumiko Sekine, Makoto Sasaki
1Gradutate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Sendai 980-8577, Japan. hfuwa@m.tohoku.ac.jp
Abstract:
Total synthesis of the proposed structure of didemnaketal B has been accomplished. The C7-C21 spiroacetal domain was synthesized by exploiting our Suzuki-Miyaura coupling/spiroacetalization strategy. The C1-C7 acyclic domain was constructed via an Evans syn-aldol reaction and a vinylogous Mukaiyama aldol reaction. Finally, the C22-C28 side chain was introduced by means of a Nozaki-Hiyama-Kishi reaction. Comparison of the NMR spectroscopic data of our synthetic material with those of the authentic sample revealed that the proposed structure requires stereochemical reassignment.
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