Related Experiment Video

Updated: May 9, 2026

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
06:03

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16

Published on: July 15, 2019

Recombinant coxsackievirus A2 and deaths of children, Hong Kong, 2012

Cyril C Y Yip1, Susanna K P Lau, Patrick C Y Woo

  • 1University of Hong Kong, Hong Kong, China.

Emerging Infectious Diseases
|July 24, 2013
PubMed

Insights

A novel coxsackievirus A2 recombinant caused severe respiratory illness in 4 children in Hong Kong, with 2 fatalities. Enhanced surveillance is crucial to control this emerging enterovirus threat.

Area of Science:

  • Virology
  • Public Health
  • Epidemiology

Background:

  • Enteroviruses are common viruses that can cause a range of illnesses.
  • Recombinant viruses can emerge through genetic reassortment of existing viral strains.
  • Coxsackievirus A2 is a known enterovirus type.

Observation:

  • A natural recombinant of coxsackievirus A2 was identified in Hong Kong in 2012.
  • The recombinant virus was detected in four children presenting with respiratory symptoms.
  • Two of the affected children unfortunately died.

Findings:

  • The emergence of a novel coxsackievirus A2 recombinant strain.
  • Association of this recombinant strain with severe respiratory disease in pediatric cases.
  • High mortality rate observed in the affected children.

Implications:

  • The need for vigilant monitoring of emerging recombinant enteroviruses.
  • Potential for international spread of this novel viral strain.
  • Importance of public health strategies to prevent enterovirus transmission.

Keywords:
Hong Kongchildrencoxsackieviruscoxsackievirus A2deathsrecombinant virusrecombinationviruses

More Related Videos

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-208:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

Development of Multiplex Real-Time RT-qPCR Assays for the Detection of SARS-CoV-2, Influenza A/B, and MERS-CoV03:53

Development of Multiplex Real-Time RT-qPCR Assays for the Detection of SARS-CoV-2, Influenza A/B, and MERS-CoV

Published on: November 10, 2023

Related Concept Videos

Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Vaccinations01:51

Vaccinations

Overview
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...