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Updated: May 9, 2026

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells
Published on: March 9, 2012
Timing it right: precise ON/OFF switches for Rho1 and Cdc42 GTPases in cytokinesis
Mohan K Balasubramanian1, Evelyn Yaqiong Tao
1Temasek Life Sciences Laboratory, 2 Department of Biological Sciences, and 3 Mechanobiology Institute, National University of Singapore, Singapore 117604.
Abstract:
In many eukaryotes, cytokinesis requires an actomyosin contractile ring that is crucial for cell constriction and new membrane organization. Two studies in this issue (Onishi et al. 2013. J. Cell Biol. http://dx.doi.org.10.1083/jcb.201302001 and Atkins et al. 2013. J. Cell Biol. http://dx.doi.org.10.1083/jcb.201301090) establish that precise activation and/or inactivation of Rho1 and Cdc42 GTPases is important for the correct order and successful completion of events downstream of actomyosin ring constriction in budding yeast.
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