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Published on: January 5, 2015
Single-Benzene-Based Clickable Fluorophores for In Vitro and In Vivo Bioimaging
Raja Mohanrao1,2, Clyde S Pinto1, Andrejus Suchenko1
1Centre for Mechanochemical Cell Biology and Warwick Medical School, Division of Biomedical Science, University of Warwick, CoventryCV4 7AL, UK.
Abstract:
A series of miniaturized, clickable single-benzene-based fluorophores derived from tetrafluoroterephthalonitrile is reported. Fluorophores based on a tetrahydroquinoxaline skeleton exhibited improved photophysical properties due to enhanced electron delocalization between donor and acceptor groups compared to those with a dihydro[1,4]thiazine skeleton. These easily synthesized clickable fluorophores were successfully applied in both in vitro and in vivo bioimaging following protein conjugation.
