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Preparation, Purification, and Use of Fatty Acid-containing Liposomes
Published on: February 9, 2018
Essential oils encapsulated in liposomes: a review
Mirna Sherry1, Catherine Charcosset, Hatem Fessi
1Faculty of Sciences, Section II, Bioactive Molecules Research Group, Doctoral School of Sciences and Technologies, Jdaidet El-Matn, Lebanese University , Lebanon and.
Journal of Liposome Research
|July 25, 2013
Summary
Essential oils, while beneficial, degrade easily. Encapsulating them in liposomes enhances their stability and biological activity, offering promising therapeutic applications.
Area of Science:
- Biochemistry
- Materials Science
- Pharmaceutical Sciences
Background:
- Essential oils (EOs) exhibit significant biological activities but are prone to degradation from oxygen, light, and temperature.
- Encapsulation in colloidal systems like liposomes is explored to enhance EO stability and delivery.
- This review specifically examines the encapsulation of EOs within liposomes.
Purpose of the Study:
- To review methods for preparing liposomes encapsulating essential oils.
- To discuss the impact of EOs and other factors on liposome characteristics (size, encapsulation efficiency, thermal behavior).
- To summarize applications of liposomes incorporating essential oils.
Main Methods:
- Preparation techniques for liposomes encapsulating essential oils.
- Analysis of liposome characteristics (size, encapsulation efficiency, thermal behavior).
- Evaluation of factors influencing liposome properties (lipid composition, EO:lipid ratio, preparation method).
Main Results:
- EOs and lipid composition significantly influence liposome size, encapsulation efficiency, and membrane fluidity.
- Certain EOs can reduce liposome size, improve dispersion, increase fluidity, and decrease lipid bilayer oxidation.
- Liposomes protect EO fluidity and demonstrate stability at 4-5°C for at least 6 months.
Conclusions:
- Liposome encapsulation enhances the stability and bioavailability of essential oils.
- Liposomes incorporating EOs show potential for increased antimicrobial activity and therapeutic applications.
- This technology offers a promising approach for developing novel drug delivery systems and studying EO interactions with cell membranes.
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