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Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Structure and Function of Leukocytes01:21

Structure and Function of Leukocytes

An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
Acute Inflammation I: Cellular Phase01:26

Acute Inflammation I: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Acute Inflammation II: Local and Systemic Effects01:25

Acute Inflammation II: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

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Related Experiment Video

Updated: May 9, 2026

Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia
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Elevated peripheral leukocyte counts in acute cervical artery dissection.

C Grond-Ginsbach1, A Giossi, S S Aksay

  • 1Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany.

European Journal of Neurology
|July 25, 2013
PubMed
Summary

Elevated white blood cell (WBC) counts were observed in patients with acute cervical artery dissection (CeAD). This finding supports a potential link between inflammation and the development of CeAD.

Keywords:
cervical artery dissectioninflammationleukocytosiswhite blood cell count

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Area of Science:

  • Neurology
  • Inflammation Research
  • Vascular Medicine

Background:

  • Inflammation's role in cervical artery dissection (CeAD) is suspected but lacks substantial evidence.
  • Existing research on inflammation markers in CeAD is limited.

Purpose of the Study:

  • To investigate the association between white blood cell (WBC) counts and acute cervical artery dissection (CeAD).
  • To compare WBC counts in CeAD patients with those in non-CeAD ischemic stroke patients and healthy controls.

Main Methods:

  • A comparative study involving 172 acute CeAD patients, 348 acute non-CeAD ischemic stroke patients, and 223 healthy controls.
  • Analysis of white blood cell (WBC) counts at admission across the three study groups.
  • Statistical comparison including multiple regression analysis adjusted for relevant covariates.

Main Results:

  • CeAD patients exhibited significantly higher WBC counts compared to both non-CeAD stroke patients and healthy controls.
  • A higher percentage of CeAD patients (38.4%) had elevated WBC counts (>10,000/μl) versus non-CeAD stroke patients (23.0%) and controls (8.5%).
  • Elevated WBC counts remained independently associated with CeAD after adjusting for age, sex, stroke severity, and vascular risk factors.

Conclusions:

  • Acute cervical artery dissection (CeAD) is strongly associated with elevated white blood cell (WBC) counts.
  • Leukocytosis in CeAD may indicate a pre-existing inflammatory state, reinforcing the link between inflammation and CeAD pathogenesis.