Related Experiment Video
Updated: May 9, 2026
Quantifiable and Inexpensive Cell-Free Fluorescent Method to Confirm the Ability of Novel Compounds to Chelate Iron
Published on: February 23, 2024
Iron, erythropoietic stimulating agents, and anemia in cancer
1Clinical Professor of Medicine, University of California, VA San Diego Healthcare System MC 111E 3350 La Jolla Village Drive, San Diego, CA 92161.
Abstract:
Anemia commonly accompanies malignancies in patients and may contribute to morbidity. Correction of the anemia with erythropoietic stimulating agents, while possible, may be associated with complications such as tumor progression and adverse cardiovascular events. This review examines the data behind these concerns and raises the strategy of using iron, alone, in the setting of cancer-associated anemia to reduce exposure to transfusions in these patients and to potentially improve their quality of life.
Related Concept Videos
01:24Factors Affecting Erythropoiesis
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
01:14Erythropoiesis
01:14Erythropoiesis
01:27Disorders of Erythrocytes
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
01:28Role of Hematopoietic Growth Factors
Thrombopoietin (TPO), mainly released by the liver,...
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...