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Updated: May 9, 2026

Bacterial Cellulose Spheres that Encapsulate Solid Materials
Published on: February 26, 2021
Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocomposite
Alexandre F Leitão1, Swati Gupta2, João Pedro Silva1
1CEB - Centre of Biological Engineering, IBB - Institute for Biotechnology and Bioengineering, Department of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
Abstract:
Bacterial cellulose (BC) has been suggested to be a suitable biomaterial for the development of cardiovascular grafts. The combination of BC with polyvinyl alcohol (PVA) results in nanocomposites with improved properties. Surprisingly, there are very few studies on the BC-blood interaction. This is the focus of this paper. We present the first thorough assessment of the hemocompatibility of the BC/PVA nanocomposite. Whole blood clotting time, plasma recalcification, Factor XII activation, platelet adhesion and activation, hemolytic index and complement activation are all determined. The platelet activation profiles on BC and BC/PVA surfaces are comprehensively characterized. BC and BC/PVA outperformed ePTFE--used as a point of comparison--thus evidencing their suitability for cardiovascular applications.

