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Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...

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Updated: May 9, 2026

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
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Published on: May 2, 2025

Correlation between platelet and brain PLA(2) activity.

Leda L Talib1, Kette D Valente, Silvia Vincentiis

  • 1Laboratory of Neuroscience-LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil.

Prostaglandins, Leukotrienes, and Essential Fatty Acids
|July 25, 2013
PubMed
Summary
This summary is machine-generated.

Platelet phospholipase A2 (PLA2) activity may reflect total brain PLA2 activity in neuropsychiatry disorders. However, drug effects may obscure correlations for specific PLA2 enzyme subtypes, necessitating further research.

Keywords:
Brain tissueEpilepsyHippocampusNeuropsychiatric disordersPLA(2)PlateletsRadioenzymatic assays

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Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
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04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

Area of Science:

  • Neuroscience
  • Biochemistry
  • Enzymology

Background:

  • Phospholipase A2 (PLA2) enzymes are linked to neuropsychiatric disorders.
  • Altered PLA2 activity is observed in both brain and platelet tissues.
  • Brain tissue is difficult to obtain for direct PLA2 activity measurement.

Purpose of the Study:

  • To investigate the correlation between PLA2 activity in platelets and brain tissue.
  • To determine if platelet PLA2 activity can serve as a surrogate marker for brain PLA2 activity.

Main Methods:

  • Assessed PLA2 activity in platelets and hippocampus simultaneously.
  • Collected samples from 19 patients undergoing temporal lobectomy for epilepsy.
  • Analyzed total PLA2 activity and specific enzyme subgroups.

Main Results:

  • A significant correlation was found between total PLA2 activity in platelets and the brain (rs=0.59, p=0.008).
  • No significant correlations were observed for specific PLA2 enzyme subgroups between platelets and brain.
  • Potential confounding effects of drug treatment on PLA2 subtypes were noted.

Conclusions:

  • Total PLA2 activity in platelets may serve as a potential indicator of brain PLA2 activity.
  • Subtype-specific PLA2 activity correlations between platelets and brain require further investigation.
  • Larger, drug-free sample studies are needed to validate platelet PLA2 activity as a reliable biomarker for brain subtypes.