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Updated: May 9, 2026

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
Published on: July 13, 2019
Standardizing central line safety: lessons learned for physician leaders
Jeff T Mueller1, Alan J Wright, Leslie A Fedraw
11Mayo Clinic, Phoenix, AZ.
Implementing a central venous catheter (CVC) safety program significantly improved best practices and reduced bloodstream infections in intensive care units (ICUs). This multidisciplinary initiative enhanced patient safety through standardized CVC care.
Area of Science:
- Healthcare Quality Improvement
- Infection Prevention
- Patient Safety
Background:
- Central venous catheters (CVCs) are essential but associated with mechanical and infectious complications.
- A multidisciplinary approach is crucial for effective CVC safety programs.
- Standardization of CVC insertion, maintenance, and removal is key to reducing adverse events.
Purpose of the Study:
- To evaluate the impact of a comprehensive CVC safety program on process measures and outcomes.
- To assess the effectiveness of a discovery and diffusion project in a multistate healthcare system.
- To identify leadership principles for future clinical improvement initiatives.
Main Methods:
- Implementation of a 12-month discovery and diffusion project focused on CVC care.
- Collection and analysis of process and outcome measures before and after the intervention.
- Focus on CVC insertion, maintenance, and removal protocols.
Main Results:
- Statistically significant improvement in 6 key process measures.
- Reduction in the rate of ICU central line-associated bloodstream infections from 1.16 to 0.80 per 1000 catheter days.
- Increased compliance with established CVC best practices.
Conclusions:
- A comprehensive CVC standardization project enhances compliance and improves patient outcomes.
- The discovery and diffusion model, coupled with strong leadership, is effective for clinical improvement.
- This initiative provides a refined definition of project components and applicable leadership principles for future endeavors.
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