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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.

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Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
09:39

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Published on: August 21, 2014

Cell cycle regulation by long non-coding RNAs.

Masatoshi Kitagawa1, Kyoko Kitagawa, Yojiro Kotake

  • 1Department of Molecular Biology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3125, Japan, kitamasa@hama-med.ac.jp.

Cellular and Molecular Life Sciences : CMLS
|July 25, 2013
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) regulate the cell cycle by controlling key proteins like cyclins and CDKs. Dysregulation of these lncRNAs is linked to cancer, offering new therapeutic targets.

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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • The cell cycle in mammals is tightly regulated by cyclin-dependent kinases (CDKs) and pathways like RB and p53.
  • Emerging evidence highlights the role of long non-coding RNAs (lncRNAs) in modulating these critical cell cycle regulators.

Purpose of the Study:

  • To explore the multifaceted roles of lncRNAs in regulating mammalian cell cycle progression.
  • To investigate the involvement of lncRNAs in DNA damage responses and their implications in tumorigenesis.

Main Methods:

  • Literature review and analysis of recent research findings on lncRNA-mediated cell cycle control.
  • Examination of lncRNA mechanisms including epigenetic, transcriptional, and post-transcriptional regulation.
  • Investigation of lncRNAs' roles in DNA damage-induced cell cycle arrest and apoptosis.

Main Results:

  • lncRNAs function as epigenetic regulators, transcription factor regulators, post-transcriptional regulators, and protein scaffolds.
  • These lncRNAs modulate the cellular levels of cyclins, CDKs, CDK inhibitors, pRB, and p53 through diverse mechanisms.
  • Certain lncRNAs are induced by DNA damage, contributing to cell cycle arrest and apoptosis as part of DNA damage responses.

Conclusions:

  • Cell cycle-regulated lncRNAs add complexity and robustness to cell cycle control.
  • Aberrant expression of these lncRNAs is implicated in cancer development.
  • lncRNAs represent promising novel molecular targets for cancer diagnosis and therapy.