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Updated: May 9, 2026
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Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery
Published on: September 19, 2014
Image-guided cancer surgery using near-infrared fluorescence
Alexander L Vahrmeijer1, Merlijn Hutteman, Joost R van der Vorst
1Department of Surgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, Netherlands. a.l.vahrmeijer@lumc.nl
Nature Reviews. Clinical Oncology
|July 25, 2013
Summary
Near-infrared (NIR) fluorescence imaging offers a promising approach to enhance cancer surgery by improving visualization and reducing costs. Further clinical validation is essential for its widespread adoption in patient care.
Area of Science:
- Surgical Oncology
- Medical Imaging
- Biomedical Optics
Background:
- Traditional cancer surgery faces limitations in achieving optimal outcomes, efficiency, and cost-effectiveness.
- Optical imaging using near-infrared (NIR) fluorescent light (700-900 nm) presents a potential solution due to enhanced contrast and tissue penetration.
- Recent years have seen a surge in clinical trials exploring NIR fluorescence imaging in surgical settings.
Purpose of the Study:
- To review the current state of NIR fluorescence imaging for cancer surgery.
- To examine existing clinical trial literature on NIR imaging in oncology.
- To identify key challenges and areas for optimization in imaging systems and contrast agents.
Main Methods:
- Literature review of proof-of-concept clinical trials in NIR fluorescence imaging for cancer surgery.
- Analysis of imaging system and contrast agent optimization factors.
- Comparison of NIR imaging with traditional surgical visualization techniques.
Main Results:
- NIR fluorescence imaging demonstrates potential for improving cancer surgery outcomes, reducing anesthesia time, and lowering healthcare costs.
- The technology offers superior contrast and tissue penetration compared to visible light imaging.
- Numerous proof-of-concept studies highlight the feasibility and benefits of NIR imaging in various cancer surgeries.
Conclusions:
- NIR fluorescence imaging is a rapidly advancing field with significant potential to revolutionize cancer surgery.
- Successful integration into routine clinical practice hinges on rigorous validation through extensive clinical trials.
- Optimization of imaging systems and contrast agents is crucial for maximizing the benefits of NIR technology in oncologic procedures.
