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Group B streptococcal meningitis in infants beyond the neonatal period

Shalini Dwivedi1, Bimal K Das, Satinder Aneja

  • 1Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

Indian Journal of Pediatrics
|July 25, 2013
PubMed

Insights

Group B Streptococcus (GBS) meningitis affects Indian infants, with PCR confirming diagnosis in most cases. Early outcomes varied, highlighting the need to consider GBS in infant meningitis.

Area of Science:

  • Pediatric Infectious Diseases
  • Bacteriology
  • Clinical Microbiology

Background:

  • Group B Streptococcus (GBS) is a significant cause of meningitis in infants.
  • Understanding the clinico-bacteriological profile and outcomes is crucial for effective management.

Purpose of the Study:

  • To detail the clinical and bacteriological characteristics of GBS meningitis in infants.
  • To assess the early outcomes of infants diagnosed with GBS meningitis.

Main Methods:

  • Retrospective review of infants (1 month to 2 years) with GBS meningitis.
  • Analysis of clinico-bacteriological data and early outcomes.
  • CSF analysis using latex agglutination test and PCR for 16s ribosomal DNA and scpB gene.

Main Results:

  • Twenty-seven infants were diagnosed with GBS meningitis.
  • PCR confirmed GBS in 16 out of 18 tested CSF samples.
  • Mortality was observed in nine patients, with some developing complications; 12 patients recovered fully.

Conclusions:

  • Group B Streptococcus (GBS) is an important etiological agent of bacterial meningitis in Indian infants.
  • Diagnostic confirmation via PCR is highly effective.
  • Clinical vigilance and further research are warranted for improved infant outcomes.
Abstract

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