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Related Concept Videos

Reporter Genes02:11

Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
Commonly used reporter...

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Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models
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Reporter gene imaging.

Hyewon Youn1, June-Key Chung

  • 1Department of Nuclear Medicine and Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea. jkchung@plaza.snu.ac.kr

AJR. American Journal of Roentgenology
|July 26, 2013
PubMed
Summary

Reporter gene imaging uses specific genes to visualize biological processes in vivo. Advances in molecular imaging enhance sensitivity, but more versatile reporter systems are needed.

Area of Science:

  • Molecular Biology
  • Biomedical Imaging

Background:

  • Reporter genes are crucial tools in molecular biology for monitoring cellular processes.
  • Various reporter genes have been developed for applications in optical imaging, nuclear medicine, and MRI.

Purpose of the Study:

  • To summarize the concept and strategies of reporter gene imaging.
  • To introduce commonly used reporter genes for in vivo applications.
  • To present typical examples of reporter gene imaging.

Main Methods:

  • Utilizing reporter genes for in vivo imaging across different modalities.
  • Placing imaging reporter genes under promoter control for dynamic visualization.
  • Leveraging instrumental advances in molecular imaging.

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Main Results:

  • Reporter gene imaging allows dynamic, in vivo visualization of gene expression, promoter activity, and protein-protein interactions.
  • Increased sensitivity and resolution in in vivo reporter imaging due to instrumental advances.

Conclusions:

  • Reporter gene systems enable dynamic monitoring of biological processes in vivo.
  • Further development is needed for more efficient multimodal reporter gene systems and detectors compatible with various imaging modalities.