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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
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Related Experiment Video

Updated: May 9, 2026

Native Polyacrylamide Gel Electrophoresis Immunoblot Analysis of Endogenous IRF5 Dimerization
08:57

Native Polyacrylamide Gel Electrophoresis Immunoblot Analysis of Endogenous IRF5 Dimerization

Published on: October 6, 2019

Interferon regulatory factor 5 and autoimmune lupus.

Wang-Dong Xu1, Hai-Feng Pan, Yuekang Xu

  • 1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, PR China.

Expert Reviews in Molecular Medicine
|July 26, 2013
PubMed
Summary

Interferon regulatory factor 5 (IRF5) gene variations are linked to systemic lupus erythematosus (SLE) onset. Understanding IRF5

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Area of Science:

  • Immunology and Genetics
  • Autoimmune Disease Research

Background:

  • Systemic lupus erythematosus (SLE) is a complex autoimmune disorder affecting multiple organ systems.
  • Interferon regulatory factor 5 (IRF5) is a transcription factor critical for immune system regulation.
  • Emerging evidence suggests a strong association between IRF5 gene polymorphisms and SLE susceptibility.

Purpose of the Study:

  • To comprehensively review current evidence on the role of IRF5 in the pathogenesis of SLE.
  • To elucidate the mechanistic links between IRF5 and the progression of autoimmune lupus.
  • To provide insights for developing novel therapeutic strategies for SLE.

Main Methods:

  • Systematic literature review of studies investigating IRF5 and SLE.
  • Analysis of evidence linking IRF5 gene polymorphisms to disease onset.
  • Examination of IRF5 expression and function in immune cells involved in SLE pathogenesis.

Main Results:

  • IRF5 is expressed in key immune cells such as B cells, dendritic cells, monocytes, and macrophages.
  • IRF5 plays a significant role in the immune cell-mediated pathogenesis of SLE.
  • Multiple studies indicate a mechanistic link between IRF5 and SLE disease progression.

Conclusions:

  • IRF5 is a critical factor in the development and progression of systemic lupus erythematosus.
  • Further understanding of IRF5's role can enhance knowledge of SLE pathogenesis.
  • Targeting IRF5 may offer potential for novel therapeutic interventions in SLE.