Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Obesity-induced hepatic steatosis is mediated by endoplasmic reticulum stress in the subfornical organ of the brain.

JCI insight·2017
Same author

Deletion of p22<sup>phox</sup>-dependent oxidative stress in the hypothalamus protects against obesity by modulating <b>β</b><sub>3</sub>-adrenergic mechanisms.

JCI insight·2017
Same author

Obesity, Hypoxemia, and Hypertension: Mechanistic Insights and Therapeutic Implications.

Hypertension (Dallas, Tex. : 1979)·2016
Same author

Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis.

Molecular metabolism·2015
Same author

Sympathetic inhibition after bariatric surgery.

Hypertension (Dallas, Tex. : 1979)·2014
Same author

Björn Folkow.

Hypertension (Dallas, Tex. : 1979)·2013
Same journal

Changes in IMCL content and storage characteristics during an acute bout of high intensity interval exercise are influenced by sex and muscle fibre type.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
Same journal

The Cardiorespiratory Response of Atlantic Salmon and Nile Tilapia to Similar Acute Thermal and Hypoxic Challenges: The Complete Story.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
Same journal

Early Life Stress Blunts Time Of Day Specific Autonomic Function In Adult Male Mice.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
Same journal

Homeostatic adaptations of the amphibious fish <i>Polypterus</i> in terrestrial environments.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
Same journal

Renal Hemodynamic and Urinary Response to Baroreflex-Mediated Sympathetic Modulation: Insights from High-Resolution Arterial Impedance Analysis in Rats.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
Same journal

Gravitational load, sex, and age-sex effects on cardiovascular compensatory responses during sit-to-stand and lie-to-stand transitions.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
See all related articles

Related Experiment Video

Updated: May 9, 2026

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice
06:16

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice

Published on: September 9, 2025

Selective leptin resistance revisited.

Allyn L Mark1

  • 1Department of Internal Medicine and the Obesity Research and Education Initiative, University of Iowa Carver College of Medicine, Iowa City, Iowa.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
|July 26, 2013
PubMed
Summary
This summary is machine-generated.

Selective leptin resistance (SLR) explains how leptin may raise blood pressure in obesity despite reduced appetite control. This review analyzes SLR mechanisms and its role in obesity-induced hypertension.

Keywords:
adipose tissueblood pressurerenalrenin-angiotensin systemsympathetic

More Related Videos

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
05:45

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing

Published on: October 25, 2019

Isolation of Targeted Hypothalamic Neurons for Studies of Hormonal, Metabolic, and Electrical Regulation
09:29

Isolation of Targeted Hypothalamic Neurons for Studies of Hormonal, Metabolic, and Electrical Regulation

Published on: August 4, 2023

Related Experiment Videos

Last Updated: May 9, 2026

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice
06:16

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice

Published on: September 9, 2025

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
05:45

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing

Published on: October 25, 2019

Isolation of Targeted Hypothalamic Neurons for Studies of Hormonal, Metabolic, and Electrical Regulation
09:29

Isolation of Targeted Hypothalamic Neurons for Studies of Hormonal, Metabolic, and Electrical Regulation

Published on: August 4, 2023

Area of Science:

  • Physiology
  • Neuroendocrinology
  • Cardiovascular Science

Background:

  • Leptin, a hormone, regulates appetite, metabolism, and neuroendocrine functions.
  • Leptin significantly impacts the sympathetic nervous system and cardiovascular system.
  • Obesity is frequently linked to hypertension, with leptin's role being a key area of investigation.

Purpose of the Study:

  • To critically review the concept of selective leptin resistance (SLR).
  • To analyze leptin's role in obesity-induced hypertension in animal models and humans.
  • To explore potential mechanisms underlying SLR.

Main Methods:

  • Review of existing literature and experimental data on leptin's actions.
  • Analysis of the selective leptin resistance (SLR) concept.
  • Examination of studies on diet-induced obesity (DIO) and genetic/acquired obesity models.

Main Results:

  • Selective leptin resistance (SLR) proposes preserved sympathetic and pressor actions of leptin in obesity despite attenuated appetite-regulating effects.
  • Potential mechanisms for SLR include differential molecular signaling and brain site-specific actions.
  • Data on leptin's effects on human sympathetic activity and blood pressure in obesity-induced hypertension remain complex.

Conclusions:

  • SLR provides a framework for understanding how leptin can contribute to hypertension in obese states.
  • Further research is needed to fully elucidate the mechanisms and broader implications of SLR.
  • Understanding leptin's complex role is crucial for managing obesity-related cardiovascular complications.