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Characterisation of mumps virus genotype C among patients with mumps in India

M Jeevan1, S Sambantham, M Thangam

  • 1Department of Microbiology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, Tamil Nadu, India.

Indian Journal of Medical Microbiology
|July 26, 2013
PubMed

Insights

Measles, mumps, and rubella (MMR) vaccine failure is now occurring in India. Genotype C mumps strains are causing infections in vaccinated individuals, necessitating vaccine improvement.

Area of Science:

  • Virology
  • Immunology
  • Public Health

Background:

  • Measles, mumps, and rubella (MMR) vaccination is a cornerstone of global public health strategies.
  • Vaccine failure, though reported globally, has not been extensively documented in India.
  • Understanding vaccine efficacy against circulating strains is crucial for disease prevention.

Observation:

  • This study documents cases of acute mumps in individuals vaccinated with the MMR vaccine in India.
  • These individuals exhibited positive results for anti-mumps immunoglobulin M, indicating recent infection.
  • The circulating mumps virus was identified as genotype C.

Findings:

  • The mumps virus genotype C identified in India is distinct from the genotype N (L-Zagreb) strain used in the current MMR vaccine.
  • This is the first report in India linking genotype C mumps to vaccine failure.
  • MMR vaccine failure is a confirmed occurrence in the Indian population.

Implications:

  • The current MMR vaccine may not provide adequate protection against the circulating genotype C mumps strain in India.
  • There is a need to revamp and optimize the MMR vaccine to enhance its efficacy against prevalent mumps genotypes.
  • Failure to address this could lead to future mumps epidemics in India, impacting public health efforts.

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