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Related Experiment Videos

Calcium homeostasis in untreated pulmonary tuberculosis II--dynamic study.

A A Hafiez1, M A Abdel-Hafez, M el-Khashab

  • 1Biochemistry Department, Cairo University, Egypt.

Kekkaku : [Tuberculosis]
|June 1, 1990
PubMed
Summary

Oral calcium tolerance tests revealed that urinary calcium significantly increased in healthy individuals but decreased in tuberculosis patients. This urinary calcium decrease in TB patients may be linked to lower 25-hydroxyvitamin D levels.

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Area of Science:

  • Biochemistry
  • Clinical Medicine
  • Endocrinology

Background:

  • Calcium homeostasis is crucial for physiological functions.
  • Tuberculosis (TB) can affect mineral metabolism.
  • Vitamin D plays a role in calcium absorption and excretion.

Purpose of the Study:

  • To investigate calcium metabolism differences between healthy controls and pulmonary tuberculosis patients.
  • To assess the impact of oral calcium loading on serum and urinary calcium levels in these groups.
  • To explore potential correlations with vitamin D and parathyroid hormone levels.

Main Methods:

  • Oral calcium tolerance test (1 gm calcium) administered to 17 normal subjects and 26 pulmonary tuberculous patients.
  • Measurement of serum calcium, urinary calcium, serum parathyroid hormone (PTH), and nephrogenous cyclic adenosine monophosphate (cAMP).

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  • Statistical analysis to compare changes between groups.

    • Main Results:

    • Oral calcium did not significantly alter serum calcium in either group.
    • Urinary calcium significantly increased in normal controls (p < 0.001) but significantly decreased in TB patients.
    • Serum 25-hydroxyvitamin D was lower in TB patients, potentially explaining the urinary calcium decrease.
    • Serum PTH and nephrogenous cAMP showed insignificant changes, indicating normal parathyroid gland function relative to serum calcium.

    Conclusions:

    • Pulmonary tuberculosis is associated with an altered urinary calcium response to oral calcium loading.
    • Reduced urinary calcium excretion in TB patients may be related to decreased 25-hydroxyvitamin D levels.
    • The parathyroid gland appears to maintain normal responsiveness to calcium fluctuations in TB patients.