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Published on: September 15, 2023
Hsa-miR-181a-5p expression and effects on cell proliferation in gastric cancer
Gang Chen1, Zhi-Li Shen, Ling Wang
1Department of Oncology, the Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.
Purpose:
MicroRNAs (miRNAs) are small endogenous, non-coding, single-stranded RNAs (approximately 22 nt). Accumulating evidence has shown that aberrant miRNA expression is pronounced and correlated with gastric cancer genesis and progression.
Materials And Methods:
Expression levels of miR-181a-5p in GC tissues and cell lines were assessed by qRT-PCR and tested for correlation with clinical features. In addition, effects of miR-181a-5p on GC cell growth were investigated.
Results:
Our findings indicate that miR-181a-5p is upregulated in GC, in correlation with lymph node invasion, nerve invasion and vascular invasion (P<0.05). Enforced expression of miR-181a -5p promoted cell proliferation ability.
Conclusions:
This study suggested that increased miR-181a-5p is related to GC progression. MiR-181a-5p may represent a potential therapeutic target for GC.
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